Understanding how a protein called FOXQ1 controls skin cell growth and repair
Bidirectional control of keratinocyte differentiation and proliferation by transcription factor FOXQ1
This research explores how a specific protein helps skin cells grow and repair themselves, which is key to maintaining healthy skin.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11112487 on NIH RePORTER |
What this research studies
Our skin acts as a vital shield against the outside world, and healthy skin cells, called keratinocytes, are essential for this protection. This project aims to understand how a protein named FOXQ1 helps control whether these skin cells grow or mature. By studying how FOXQ1 works with calcium levels in the skin, we hope to uncover the basic mechanisms that keep our skin healthy. This knowledge could eventually lead to new ways to help people with various skin conditions.
Who could benefit from this research
Good fit: This foundational laboratory research does not directly involve patient participation, but future studies building on this work may seek individuals with skin conditions related to cell growth and differentiation.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could provide fundamental insights into skin health and disease, potentially leading to new treatments for conditions like atopic dermatitis.
How similar studies have performed: This research explores a novel regulatory mechanism of the FOXQ1 protein in skin cells, building on initial findings by the research team.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Nikiforov, Mikhail — Duke University
- Study coordinator: Nikiforov, Mikhail
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.