Understanding how a protein called FBW7 affects kidney cyst growth
Role of FBW7 in cystic diseases of the kidney
This research explores how a specific protein called FBW7 contributes to the development of kidney cysts in various forms of Polycystic Kidney Disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-11167661 on NIH RePORTER |
What this research studies
Polycystic Kidney Disease (PKD) includes several genetic conditions where fluid-filled sacs, or cysts, grow in the kidneys. While we know some things about how these cysts form, the exact steps that change kidney cells and lead to cyst growth are not fully clear. This project focuses on a protein called FBW7 and how it influences these changes, as well as other factors like cell signaling and inflammation. By understanding these processes better, we hope to find new and more effective ways to treat PKD.
Who could benefit from this research
Good fit: This foundational research is relevant to patients of all ages affected by Autosomal Dominant Polycystic Kidney Disease (ADPKD), Autosomal Recessive Polycystic Kidney Disease, Nephronophthisis (NPHP), and Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD).
Not a fit: Patients whose kidney disease is not related to cyst formation or the specific genetic conditions mentioned may not directly benefit from this particular line of research.
Why it matters
Potential benefit: If successful, this work could lead to the discovery of new drug targets and more effective treatments for patients with various forms of Polycystic Kidney Disease.
How similar studies have performed: This research builds upon existing knowledge of kidney cyst development, aiming to uncover novel mechanisms for future treatments.
Where this research is happening
Oklahoma City, United States
- University of Oklahoma Hlth Sciences Ctr — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Tsiokas, Leonidas — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Tsiokas, Leonidas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.