Understanding how a protein called DPEP1 helps adenomas become colorectal cancer
Shaping the Microenvironment by DPEP1 Facilitates Adenoma Progression
This project looks at how a protein called DPEP1 in the gut might help non-cancerous growths, called adenomas, turn into colorectal cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11176207 on NIH RePORTER |
What this research studies
We are learning how a protein called DPEP1 might play a role in the development of colorectal cancer from adenomas, which are growths in the colon. Our work suggests that DPEP1 helps these adenomas communicate with immune cells called neutrophils, creating an environment that encourages the adenomas to progress. By studying human tissue samples, healthy volunteer cells, and lab models, we aim to understand this communication better. This knowledge could help us identify which adenomas are more likely to become cancerous and find new ways to prevent colorectal cancer.
Who could benefit from this research
Good fit: Patients with colorectal adenomas or those at risk for colorectal cancer may eventually benefit from the insights gained from this fundamental research.
Not a fit: Patients without adenomas or colorectal cancer would not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify adenomas at high risk of becoming cancerous and develop strategies to prevent colorectal cancer.
How similar studies have performed: This work builds on recent discoveries about DPEP1's functions and its presence in adenomas and colorectal cancers, suggesting a novel approach to understanding progression.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Coffey, Robert J. — Vanderbilt University Medical Center
- Study coordinator: Coffey, Robert J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.