Understanding how a protein called CD151 affects Alzheimer's disease
The role of tetraspanin-regulated endolysosomal trafficking in Alzheimer's Disease
This research explores how a specific protein and cell processes might contribute to the development of Alzheimer's disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-11177003 on NIH RePORTER |
What this research studies
Alzheimer's disease involves the buildup of harmful proteins, leading to inflammation and nerve damage. Scientists believe that problems with how cells process and clear waste, specifically within the 'endolysosomal network,' could be an early cause of the disease. This project will look at a protein called CD151, which appears to help these cell processes work correctly and prevent the release of harmful substances. We aim to understand exactly how CD151 helps maintain healthy cell function and how its absence might lead to Alzheimer's.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to understand the disease mechanisms relevant to individuals with sporadic, late-onset Alzheimer's disease.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this research could uncover new ways to prevent or treat Alzheimer's disease by targeting these specific cell processes.
How similar studies have performed: This project builds on recent findings about CD151's role in cell processes, suggesting a novel approach to understanding Alzheimer's disease.
Where this research is happening
Oklahoma City, United States
- Oklahoma Medical Research Foundation — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Rice, Heather C. — Oklahoma Medical Research Foundation
- Study coordinator: Rice, Heather C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.