Understanding how a protein called Calreticulin behaves in prostate cancer
Official title: Role of Calreticulin Acetylation on Trafficking in Prostate Cancer
Funded at South Carolina State University · NIH-10807588 · Data updated 2026-11-12
This study is looking at a protein called Calreticulin that helps cancer cells in prostate cancer manage calcium, to see how it affects the way the immune system spots and fights these cells, which could lead to better treatment options for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | South Carolina State University NIH-funded |
| Lab location | 1 site (Orangeburg, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $147,057 |
| NIH project number | 1K01CA280185-01A1 |
| Project ID | NIH-10807588 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men diagnosed with prostate cancer, particularly those interested in understanding the molecular mechanisms of their disease.
✕Less likely to help
Patients with non-cancerous conditions or those with cancers other than prostate cancer may not receive any benefit from this research.
What this research studies
This research investigates the role of Calreticulin (CRT), a protein that helps cells manage calcium, in the context of prostate cancer. The study aims to understand how CRT is modified and transported to the surface of cancer cells, which may influence how the immune system recognizes and attacks these cells. By examining the acetylation of CRT, the research seeks to uncover new insights into its behavior in prostate cancer, potentially leading to improved treatment strategies. Patients may benefit from a deeper understanding of how their cancer cells interact with the immune system.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance the immune response against prostate cancer.
How similar studies have gone: While the specific focus on CRT acetylation in prostate cancer is novel, similar studies have shown that understanding protein modifications can lead to significant advancements in cancer treatment.
Where this research is happening
-
South Carolina State University
Orangeburg, United States Active
Researchers
- Principal investigator: Thomas, Courtney — South Carolina State University
- Study coordinator: Thomas, Courtney
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.