Understanding how a protein called C1QL3 helps form connections in the brain
Official title: Molecular mechanism of the synapse organizer C1QL3
Funded at University of Connecticut Sch of Med/dnt · NIH-11118285 · Data updated 2026-11-12
This study is looking at a protein called C1QL3 to see how it helps brain cells connect with each other, which is important for communication, and it could help us understand some brain disorders that are linked to genetics.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $249,750 |
| NIH project number | 1R21NS142751-01 |
| Project ID | NIH-11118285 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic variants linked to neurological disorders that affect synaptic function.
✕Less likely to help
Patients without genetic variants related to synaptic adhesion molecules or those not experiencing neurological disorders may not benefit from this research.
What this research studies
This research investigates the role of the protein C1QL3 in the formation of synapses, which are essential for communication between brain cells. By studying how C1QL3 interacts with other proteins and influences synaptic development, the researchers aim to uncover the mechanisms behind certain neurological disorders linked to genetic variants of synaptic adhesion molecules. The approach includes examining the effects of C1QL3 on synapse density and its interactions with other proteins involved in synaptic function. This research could provide insights into how disruptions in these processes may lead to behavioral impairments.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurological disorders associated with synaptic dysfunction.
How similar studies have gone: Previous research has shown that understanding synaptic adhesion molecules can lead to significant insights into neurological disorders, suggesting that this approach has potential for success.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Hao, Bing — University of Connecticut Sch of Med/dnt
- Study coordinator: Hao, Bing
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.