Understanding how a protein called ATF6 affects beta cells in type 1 diabetes
The role of beta cell ATF6 in type 1 diabetes
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11120996
This work explores how stress in pancreatic beta cells, involving a protein called ATF6, contributes to type 1 diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11120996 on ClinicalTrials.gov |
What this research studies
Type 1 diabetes happens when the body's immune system mistakenly destroys the beta cells in the pancreas that make insulin. While this is an immune problem, we are learning that stress within the beta cells themselves also plays a big part in their destruction. This project looks at a specific stress response pathway, called the unfolded protein response, and a key protein within it, ATF6. By understanding how ATF6 helps beta cells survive or causes them to die under stress, we hope to find new ways to protect these vital cells. This research uses advanced models to uncover these hidden mechanisms.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future clinical applications would target individuals with type 1 diabetes.
Not a fit: Patients without type 1 diabetes or those whose beta cell function is not related to ATF6 stress responses may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect insulin-producing beta cells from destruction in people with type 1 diabetes.
How similar studies have performed: While the general concept of beta cell stress in diabetes is known, this specific focus on ATF6's role in type 1 diabetes using advanced genetic models is a novel approach.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ENGIN, FEYZA — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: ENGIN, FEYZA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.