Understanding how a protein called APP works in Alzheimer's
Mechanisms of APP ectodomain function
This work aims to uncover the normal functions of a specific part of a protein called APP, which is important in Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-11123999 on NIH RePORTER |
What this research studies
Our bodies have many proteins on cell surfaces that help cells communicate and function properly. A key part of these proteins, called the ectodomain, can be released from the cell surface and play new roles. The Amyloid Precursor Protein (APP) is one such protein, and it is central to Alzheimer's disease. While much attention has been on other aspects of APP, we want to understand the normal, healthy functions of its ectodomain. This involves exploring how these APP fragments interact with other cell components, like the GABA type B Receptor, to better understand their role in brain health.
Who could benefit from this research
Good fit: This foundational research is relevant to patients living with Alzheimer's disease and their families, as it seeks to understand the disease's basic mechanisms.
Not a fit: Patients not affected by Alzheimer's disease would not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of Alzheimer's disease, potentially identifying new targets for future treatments.
How similar studies have performed: This approach builds on recent discoveries about how APP fragments interact with other receptors, suggesting a novel direction for understanding its function.
Where this research is happening
Oklahoma City, United States
- Oklahoma Medical Research Foundation — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Rice, Heather C. — Oklahoma Medical Research Foundation
- Study coordinator: Rice, Heather C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.