Understanding how a protein called ALIX works in our cells
The Functional Interplay Between Phase Separation, Fibrillization, and Posttranslational Modifications of ALIX
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11141141
This project explores how a key protein named ALIX changes shape and interacts with other molecules to control important cell processes like cell death and how viruses leave cells.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11141141 on ClinicalTrials.gov |
What this research studies
Our cells rely on a protein called ALIX for many vital tasks, including managing cell waste, programmed cell death, and even how certain viruses spread. We've found that ALIX can form different structures, like liquid droplets and tiny fibers, which are controlled by chemical changes to the protein. This work aims to understand the exact shapes of these structures, how they are regulated by these chemical changes and cell membranes, and what role they play in cell functions. We also want to learn how ALIX's ability to form these structures connects with other cellular signals.
Who could benefit from this research
Good fit: This foundational biological work does not directly involve patient participation at this stage, but future applications could benefit patients with conditions related to cell death, viral infections, or cellular waste management.
Not a fit: Patients seeking immediate new treatments or direct clinical interventions would not find direct benefit from this basic science project.
Why it matters
Potential benefit: A deeper understanding of ALIX's functions could lead to new ways to address diseases involving cell death, viral infections, or issues with cell communication.
How similar studies have performed: This project builds upon recent discoveries about ALIX's ability to form liquid-like condensates and amyloid fibrils, exploring novel aspects of their regulation and function.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DESHMUKH, LALIT — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: DESHMUKH, LALIT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.