Understanding how a protein called AID affects immune cells and cancer
RNA-directed targeting of AID in immunity and cancer
['FUNDING_R01'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11121057
This project looks at how a protein called AID works in immune cells to help us understand both healthy immune responses and certain cancers like lymphoma.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11121057 on ClinicalTrials.gov |
What this research studies
Our immune system's B cells use a protein called AID to create diverse antibodies, which is important for fighting infections. However, when AID doesn't work correctly, it can cause damage to DNA, potentially leading to serious conditions like lymphoma, a type of blood cancer. This work explores how AID is guided to specific DNA locations and how it might influence other genes in B cells. By understanding these processes, we hope to uncover new ways to support a healthy immune system and prevent or treat B cell cancers.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit those with B cell lymphomas or immune system disorders in the future.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to understand and potentially treat B cell lymphomas and improve immune health.
How similar studies have performed: This project builds upon existing knowledge of AID's role in immunity and cancer, exploring novel mechanisms of its regulation and function.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHAUDHURI, JAYANTA — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: CHAUDHURI, JAYANTA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.