Understanding how a protein called A20 affects skin and joint disease in psoriasis
Restriction of psoriatic skin and joint disease by A20
This study is looking at how a protein called A20 affects skin and joint problems in people with psoriasis, hoping to find out more about the immune system's role in causing arthritis, which could help improve treatments for those who suffer from these conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11000306 on NIH RePORTER |
What this research studies
This research investigates the role of the A20 protein in the development of psoriatic skin and joint disease. It aims to uncover the immune mechanisms that lead to arthritis in patients with psoriasis, focusing on how A20 regulates inflammatory responses. The study will utilize mouse models to explore the specific immune cells and cytokines involved in this process, providing insights that could lead to better treatment strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with psoriasis, particularly those who may also be experiencing joint pain or arthritis.
Not a fit: Patients without psoriasis or those whose joint issues are unrelated to psoriatic disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients suffering from both psoriasis and psoriatic arthritis.
How similar studies have performed: Previous research has shown promising results in understanding inflammatory pathways in psoriasis, but the specific role of A20 in this context is still being explored.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Razani, Bahram — University of California, San Francisco
- Study coordinator: Razani, Bahram
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.