Understanding how a protein and cholesterol affect pain relief through opioid receptors
Official title: Defining the mechanism of PTCHD1 and membrane cholesterol in the regulation of the mu-opioid receptor
Funded at University of Florida · NIH-10996216 · Data updated 2026-11-12
This study is looking at how a protein called PTCHD1 and cholesterol in cell membranes affect how well the mu-opioid receptor works, which is important for pain relief, to find better ways to manage pain safely.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $74,284 |
| NIH project number | 1F32GM155989-01 |
| Project ID | NIH-10996216 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from acute pain conditions who may benefit from enhanced analgesic therapies.
✕Less likely to help
Patients who do not experience pain or have chronic pain conditions not related to opioid receptors may not benefit from this research.
What this research studies
This research investigates the role of a protein called PTCHD1 and the presence of cholesterol in the cell membrane on the function of the mu-opioid receptor, which is crucial for pain relief. By studying how these factors influence the receptor's ability to respond to opioids, the research aims to uncover new mechanisms that could enhance pain management. The approach involves examining cellular responses and the local membrane environment to determine how they affect opioid efficacy and tolerance. This could lead to improved strategies for treating pain without the risks associated with current opioid therapies.
Why it matters
Potential benefit: If successful, this research could lead to more effective pain relief treatments with fewer side effects and reduced risk of opioid dependence.
How similar studies have gone: Other research has shown promising results in understanding GPCR regulation, but the specific role of PTCHD1 in opioid receptor function is relatively novel.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Lankford, Colten Keith — University of Florida
- Study coordinator: Lankford, Colten Keith
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.