Understanding how a protein affects uterine health and pregnancy.
The Role of SRF in Uterine Homeostasis
This study is looking at how a protein called serum response factor (SRF) affects hormone signals in the uterus that are important for getting and staying pregnant, with the hope of finding better ways to help women who have trouble with pregnancy or other uterine issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | U.s. National Inst of Environ Hlth Scis NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10933112 on NIH RePORTER |
What this research studies
This research investigates the role of serum response factor (SRF) in the uterus, particularly how it influences progesterone signaling, which is crucial for establishing and maintaining pregnancy. By examining how SRF interacts with other factors to regulate gene expression in uterine cells, the research aims to uncover mechanisms that could lead to better diagnosis and treatment of recurrent pregnancy loss and inflammatory gynecological diseases. The study employs advanced techniques like ATAC sequencing to analyze gene regulation and cellular responses in the uterine environment. Ultimately, this research seeks to improve understanding of uterine health and fertility.
Who could benefit from this research
Good fit: Ideal candidates for this research are women aged 21 and older who have experienced recurrent pregnancy loss or have difficulty conceiving.
Not a fit: Patients who are not experiencing reproductive health issues or those who are not of childbearing age may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for women experiencing recurrent pregnancy loss and other fertility issues.
How similar studies have performed: Previous research has shown promising results in understanding the role of gene regulation in reproductive health, suggesting that this approach could yield valuable insights.
Where this research is happening
Durham, United States
- U.s. National Inst of Environ Hlth Scis — Durham, United States (Active)
Researchers
- Principal investigator: Marquardt, Ryan — U.s. National Inst of Environ Hlth Scis
- Study coordinator: Marquardt, Ryan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.