Understanding how a protein affects tooth and bone health
Functional domains of bone sialoprotein in dentoalveolar development and healing
This study is looking at a special protein that helps with the growth and healing of teeth and gums, which could lead to better treatments for people with gum disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10995275 on NIH RePORTER |
What this research studies
This research investigates the role of bone sialoprotein in the development and healing of dental and periodontal tissues. By focusing on how this protein influences the formation of cementum and alveolar bone, the study aims to uncover mechanisms that could improve treatments for periodontal disease. Patients with periodontal issues may benefit from insights gained about tissue regeneration and repair, potentially leading to more effective therapies. The research employs a combination of molecular biology techniques and animal models to explore these biological processes.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults over 65 years old who are experiencing periodontal disease or related dental issues.
Not a fit: Patients with no dental issues or those under 21 years old may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for periodontal disease, enhancing oral health and overall quality of life for patients.
How similar studies have performed: Previous research has shown promise in understanding the role of extracellular matrix proteins in tissue regeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Chavez, Michael B. — Ohio State University
- Study coordinator: Chavez, Michael B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.