Understanding how a protein affects tooth and bone health
Functional domains of bone sialoprotein in dentoalveolar development and healing
This study is looking at a special protein that helps with the growth and healing of teeth and gums, hoping to find ways to improve treatments for gum disease, especially for adults over 65.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10631878 on NIH RePORTER |
What this research studies
This research investigates the role of bone sialoprotein in the development and healing of dental and periodontal tissues. By examining how this protein influences the mineralization of cementum and alveolar bone, the study aims to uncover mechanisms that could enhance the repair and regeneration of periodontal tissues. Patients may benefit from insights that could lead to improved treatments for periodontal disease, which is prevalent among adults, especially those over 65. The research employs biological assays to analyze the functional domains of bone sialoprotein and their impact on oral health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults, particularly those over 65 years old, who are experiencing periodontal disease or related oral health issues.
Not a fit: Patients with no dental or periodontal issues may not receive any direct benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for periodontal disease, improving oral health and overall quality of life for patients.
How similar studies have performed: Previous research has shown promise in understanding the role of extracellular matrix proteins in tissue regeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Chavez, Michael B. — Ohio State University
- Study coordinator: Chavez, Michael B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.