Understanding how a protein affects the function of cell organelles involved in metabolism
Determining the Role of p97 Adaptor UBXD8 in Peroxisome Function
This study is looking at a protein called UBXD8 to see how it affects tiny parts of our cells called peroxisomes, which help with important body processes, and the findings could lead to better understanding and treatments for conditions like heart disease, cancer, and diabetes.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10904016 on NIH RePORTER |
What this research studies
This research investigates the role of the UBXD8 protein in the function of peroxisomes, which are essential organelles involved in various metabolic processes in the body. By examining how UBXD8 influences the abundance and degradation of peroxisomes, the study aims to uncover mechanisms that could be linked to diseases such as heart disease, cancer, and diabetes. The approach includes quantitative proteomic studies and analyses of cellular metabolism to understand the relationship between UBXD8 and peroxisome function. Patients may benefit from insights gained about metabolic disorders and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with metabolic disorders, particularly those related to peroxisome deficiencies, such as inherited neuropathologies, heart disease, or diabetes.
Not a fit: Patients with conditions unrelated to metabolic dysfunction or peroxisome activity may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating metabolic disorders associated with peroxisome dysfunction.
How similar studies have performed: While the specific role of UBXD8 in peroxisome function is being explored, similar research has shown promise in understanding the impact of organelle function on metabolic diseases.
Where this research is happening
Boston, United States
- Tufts University Boston — Boston, United States (Active)
Researchers
- Principal investigator: Montes, Iris — Tufts University Boston
- Study coordinator: Montes, Iris
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.