Understanding how a protein affects muscle relaxation during pregnancy
Official title: Post-translational Modification of Cx43 Regulates Myometrial Quiescence
Funded at University of Nevada Reno · NIH-10784717 · Data updated 2026-11-12
This study is looking at how a protein called connexin 43 helps relax the muscles in the uterus during pregnancy, especially when the uterus stretches and gets more blood flow, with the goal of finding new ways to prevent preterm labor for those who might be at higher risk.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Reno NIH-funded |
| Lab location | 1 site (Reno, United States) |
| Project start | February 15, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $183,750 |
| NIH project number | 5R21HD108728-02 |
| Project ID | NIH-10784717 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant women, especially those at risk of preterm labor or those who have experienced it in previous pregnancies.
✕Less likely to help
Patients who are not pregnant or those who have no history of preterm labor may not benefit from this research.
What this research studies
This research investigates the role of a protein called connexin 43 (Cx43) in regulating the relaxation of the uterine muscles during pregnancy. The study focuses on how mechanical stretching and increased blood flow to the uterus can lead to the production of nitric oxide, which modifies Cx43 and helps maintain muscle quiescence. By exploring these mechanisms, the research aims to identify new therapeutic targets for preventing preterm labor, particularly in populations that are disproportionately affected. The approach includes examining human pregnancy tissues to better understand the biological processes involved.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective therapies to prevent preterm labor, improving outcomes for both mothers and infants.
How similar studies have gone: Previous research has shown promise in targeting similar biological mechanisms for managing preterm labor, but this specific approach is novel.
Where this research is happening
-
University of Nevada Reno
Reno, United States Active
Researchers
- Principal investigator: Buxton, Iain L — University of Nevada Reno
- Study coordinator: Buxton, Iain L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.