Understanding how a protein affects muscle health as we age
Official title: Investigating TFEB as a critical node to improve proteostatic maintenance and skeletal muscle function with age
Funded at Oklahoma Medical Research Foundation · NIH-11055196 · Data updated 2026-11-12
This study is looking at how a protein called TFEB helps keep our muscles healthy as we get older, and it hopes to find ways to improve muscle recovery and function for older adults who may be experiencing muscle problems.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $135,057 |
| NIH project number | 1K99AG086524-01A1 |
| Project ID | NIH-11055196 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing muscle weakness or atrophy due to aging.
✕Less likely to help
Patients who are younger and do not have any muscle-related issues may not receive benefit from this research.
What this research studies
This research investigates the role of a protein called TFEB in maintaining muscle health and function as people age. It aims to understand how aging affects muscle cells and why they become less effective over time. By studying the mechanisms behind muscle deterioration, the research seeks to identify potential ways to enhance muscle recovery and function in older adults. Patients may benefit from insights that could lead to new treatments for age-related muscle issues.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving muscle function and quality of life in older adults.
How similar studies have gone: Previous research has shown promising results in understanding muscle function and degradation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Fuqua, Jordan — Oklahoma Medical Research Foundation
- Study coordinator: Fuqua, Jordan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.