Understanding how a protein affects muscle function using zebrafish.
Official title: Skeletal Myosin-Binding Protein C: Defining Function Across Scales Using a Zebrafish Model System.
Funded at University of Vermont & St Agric College · NIH-10951952 · Data updated 2026-11-12
This study is looking at how a protein called MyBP-C affects muscle movement using zebrafish, which helps researchers understand muscle diseases like distal arthrogryposis and find new ways to treat them.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project start | September 5, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $201,960 |
| NIH project number | 1R21AR084767-01 |
| Project ID | NIH-10951952 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic mutations affecting MyBP-C, particularly those diagnosed with skeletal myopathies such as distal arthrogryposis.
✕Less likely to help
Patients with muscle disorders not linked to MyBP-C mutations or those with unrelated conditions may not benefit from this research.
What this research studies
This research investigates the role of Myosin-binding protein C (MyBP-C) in muscle contractility by utilizing a zebrafish model. Researchers will employ advanced CRISPR technology to create zebrafish that express specific MyBP-C isoforms, allowing them to study how these proteins influence muscle function and how mutations may lead to conditions like distal arthrogryposis. By observing the effects of these proteins in a living organism, the research aims to provide insights into muscle diseases and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of muscle disorders and pave the way for new treatments for patients with skeletal myopathies.
How similar studies have gone: Other research has successfully utilized zebrafish models to study muscle function and genetic mutations, indicating a promising approach for this investigation.
Where this research is happening
-
University of Vermont & St Agric College
Burlington, United States Active
Researchers
- Principal investigator: Warshaw, David M — University of Vermont & St Agric College
- Study coordinator: Warshaw, David M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.