Understanding how a protein affects muscle function using zebrafish.
Skeletal Myosin-Binding Protein C: Defining Function Across Scales Using a Zebrafish Model System.
['FUNDING_R21'] · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · NIH-10951952
This study is looking at how a protein called MyBP-C affects muscle movement using zebrafish, which helps researchers understand muscle diseases like distal arthrogryposis and find new ways to treat them.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VERMONT & ST AGRIC COLLEGE (nih funded) |
| Locations | 1 site (BURLINGTON, UNITED STATES) |
| Trial ID | NIH-10951952 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Myosin-binding protein C (MyBP-C) in muscle contractility by utilizing a zebrafish model. Researchers will employ advanced CRISPR technology to create zebrafish that express specific MyBP-C isoforms, allowing them to study how these proteins influence muscle function and how mutations may lead to conditions like distal arthrogryposis. By observing the effects of these proteins in a living organism, the research aims to provide insights into muscle diseases and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic mutations affecting MyBP-C, particularly those diagnosed with skeletal myopathies such as distal arthrogryposis.
Not a fit: Patients with muscle disorders not linked to MyBP-C mutations or those with unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of muscle disorders and pave the way for new treatments for patients with skeletal myopathies.
How similar studies have performed: Other research has successfully utilized zebrafish models to study muscle function and genetic mutations, indicating a promising approach for this investigation.
Where this research is happening
BURLINGTON, UNITED STATES
- UNIVERSITY OF VERMONT & ST AGRIC COLLEGE — BURLINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WARSHAW, DAVID M — UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
- Study coordinator: WARSHAW, DAVID M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.