Understanding how a protein affects Lyme disease transmission
PlzA, cyclic-di-GMP and the enzootic cycle for Lyme disease
This study is looking at a protein called PlzA in Lyme disease bacteria to see how it helps the bacteria survive and spread, which could help us understand how Lyme disease is passed from ticks to people.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-10974034 on NIH RePORTER |
What this research studies
This research investigates the role of a specific protein, PlzA, in the lifecycle of Lyme disease-causing bacteria. By analyzing how this protein interacts with a signaling molecule called cyclic-di-GMP, researchers aim to understand how the bacteria adapt to their environment. The study involves creating genetically modified strains of the bacteria to observe how changes in the PlzA protein affect their ability to infect ticks and mammals. This could provide insights into the mechanisms behind Lyme disease transmission.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living in areas where Lyme disease is prevalent, particularly those who have had exposure to ticks.
Not a fit: Patients who do not live in Lyme disease-endemic areas or those who have not been exposed to ticks may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing Lyme disease transmission.
How similar studies have performed: Other research has shown promise in understanding bacterial adaptations and their implications for disease transmission, making this approach potentially impactful.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Marconi, Richard T — Virginia Commonwealth University
- Study coordinator: Marconi, Richard T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.