Understanding how a protein affects Lyme disease spread and infection
OspC and its role in defining host range and dissemination properties
This study is looking at how certain parts of a protein from the Lyme disease bacteria can change the way the bacteria infects and spreads, which could help create better vaccines and tests for people dealing with Lyme disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-10889123 on NIH RePORTER |
What this research studies
This research focuses on Lyme disease, the most prevalent tick-borne illness in the northern hemisphere, which is becoming more common due to the expanding Ixodes tick population. The project aims to identify key features of outer surface protein C (OspC), a vital factor for the bacteria that cause Lyme disease. By using advanced genetic techniques, the researchers will explore how variations in OspC affect the bacteria's ability to infect and spread. The findings could contribute to the development of better vaccines and diagnostic tools for Lyme disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of Lyme disease, particularly those living in areas with high tick populations.
Not a fit: Patients who are not at risk for Lyme disease or those who have already been diagnosed and treated may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines and diagnostic methods for Lyme disease, enhancing patient care and prevention.
How similar studies have performed: Previous research has shown promise in understanding the role of bacterial proteins in disease, indicating that this approach could yield valuable insights.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Marconi, Richard T — Virginia Commonwealth University
- Study coordinator: Marconi, Richard T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.