Understanding how a protein affects lung injury and survival in sepsis
Official title: Investigating the Role of HDL-Associated Serum Amyloid A in Sepsis-Induced Acute Lung Injury and Mortality
Funded at University of Kentucky · NIH-11047774 · Data updated 2026-11-12
This study is looking at how a protein called Serum Amyloid A (SAA) affects lung health and survival in people with sepsis, a serious infection, to find new ways to help patients recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $699,385 |
| NIH project number | 1R01HL173026-01A1 |
| Project ID | NIH-11047774 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with sepsis or at high risk for developing sepsis.
✕Less likely to help
Patients with sepsis who do not have elevated levels of HDL or SAA may not benefit from this research.
What this research studies
This research investigates the role of Serum Amyloid A (SAA), a protein associated with high-density lipoprotein (HDL), in the context of sepsis, a severe immune response to infection. The study aims to understand how SAA influences lung injury and mortality rates in sepsis through experiments using animal models. By examining the effects of SAA on immune response and lung health, the researchers hope to identify new therapeutic strategies that could improve survival rates for patients suffering from sepsis.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve survival rates for patients with sepsis.
How similar studies have gone: Previous studies have shown that manipulating HDL levels can impact sepsis outcomes, suggesting that this approach may hold promise.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Shridas, Preetha — University of Kentucky
- Study coordinator: Shridas, Preetha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.