Understanding how a protein affects lung fibrosis.
Official title: Post-Transcriptional Regulation of Lung Fibrosis.
Funded at University of Alabama at Birmingham · NIH-11109667 · Data updated 2026-11-12
This study is looking at how a protein called KSRP affects lung scarring in people with idiopathic pulmonary fibrosis (IPF) and hopes to find new ways to treat this condition by understanding how KSRP works in lung cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 5, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $557,151 |
| NIH project number | 5R01HL167010-03 |
| Project ID | NIH-11109667 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with idiopathic pulmonary fibrosis.
✕Less likely to help
Patients with other forms of lung disease or those without a diagnosis of pulmonary fibrosis may not benefit from this research.
What this research studies
This research investigates the role of a specific protein, KH-Type Splicing Regulatory Protein (KSRP), in the development of idiopathic pulmonary fibrosis (IPF), a serious lung disease characterized by excessive scarring. The study aims to uncover how decreased levels of KSRP in lung cells contribute to the activation of myofibroblasts, which are cells that promote fibrosis. By using animal models, the researchers will explore the mechanisms by which KSRP regulates the production of extracellular matrix proteins and myofibroblast differentiation. This could lead to new insights into potential therapeutic targets for treating IPF.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of lung fibrosis in patients.
How similar studies have gone: Previous research has shown that targeting molecular mechanisms involved in fibrosis can lead to significant advancements in treatment, suggesting potential success for this approach.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Che, Pulin — University of Alabama at Birmingham
- Study coordinator: Che, Pulin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.