Understanding how a protein affects immune cells called neutrophils
Official title: Defining the role of PSTPIP2 in neutrophil biology
Funded at Cedars-Sinai Medical Center · NIH-10901433 · Data updated 2026-11-12
This study is looking at a protein called PSTPIP2 to see how it affects immune cells called neutrophils, which help fight infections and inflammation, and it’s for anyone interested in understanding how changes in this protein might lead to better treatments for inflammatory diseases and infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | December 18, 2024 |
| Project end | December 17, 2027 |
| Funding year | 2024 |
| Award (this year) | $73,828 |
| NIH project number | 1F32AI183661-01 |
| Project ID | NIH-10901433 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to neutrophil dysfunction, such as chronic inflammatory diseases or recurrent infections.
✕Less likely to help
Patients with conditions unrelated to neutrophil function or those who do not have inflammatory diseases may not benefit from this research.
What this research studies
This research investigates the role of a protein known as PSTPIP2 in the function and development of neutrophils, which are essential immune cells that respond to infections and inflammation. The study aims to uncover how PSTPIP2 regulates neutrophil behavior, particularly in conditions where neutrophil function is altered, leading to diseases. By examining mice that lack this protein, researchers will explore the consequences on neutrophil numbers and their inflammatory responses. The findings could help identify new therapeutic targets for treating inflammatory diseases and recurrent infections.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from inflammatory diseases and recurrent infections by targeting neutrophil function.
How similar studies have gone: Other research has shown success in understanding immune cell functions and their regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Ratitong, Bridget — Cedars-Sinai Medical Center
- Study coordinator: Ratitong, Bridget
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.