Understanding how a protein affects immune cell function during gut inflammation
Official title: CD45 mediated regulation of PMN function during intestinal inflammation
Funded at University of Michigan at Ann Arbor · NIH-11166891 · Data updated 2026-11-12
This study is looking at how a protein called CD45 affects immune cells called neutrophils during gut inflammation, like in inflammatory bowel disease, to see if changing how this protein works can help improve the body's response to inflammation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 16, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $497,370 |
| NIH project number | 1R56DK140172-01 |
| Project ID | NIH-11166891 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from inflammatory bowel diseases such as Crohn's disease or ulcerative colitis.
✕Less likely to help
Patients with non-inflammatory gastrointestinal disorders or those without neutrophil-related complications may not benefit from this research.
What this research studies
This research investigates the role of the protein CD45 in regulating the function of neutrophils, a type of immune cell, during intestinal inflammation, particularly in conditions like inflammatory bowel disease. By using specially designed mice that lack CD45 in their neutrophils, the researchers aim to understand how this protein influences the movement and activity of these immune cells in the gut. The study will explore the signaling pathways involved in neutrophil behavior and how targeting specific forms of CD45 could potentially alter inflammatory responses.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage inflammation in patients with intestinal diseases.
How similar studies have gone: Previous research has shown that targeting immune cell signaling pathways can lead to significant improvements in managing inflammatory conditions, suggesting potential success for this approach.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Brazil, Jennifer C — University of Michigan at Ann Arbor
- Study coordinator: Brazil, Jennifer C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.