Understanding how a protein affects heart muscle function in hypertrophic cardiomyopathy
Structural Dynamics of Cardiac Myosin-Binding Protein C Regulation
['FUNDING_R01'] · UNIVERSITY OF ARIZONA · NIH-11045795
This study is looking at a protein called MyBP-C to see how it affects heart function in people with hypertrophic cardiomyopathy (HCM), and it hopes to find new ways to help treat this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-11045795 on ClinicalTrials.gov |
What this research studies
This research investigates the role of cardiac myosin-binding protein C (MyBP-C) in hypertrophic cardiomyopathy (HCM), a condition that affects heart muscle function. The study aims to understand how MyBP-C interacts with actin and myosin, the proteins responsible for heart muscle contraction, under various conditions, including mutations associated with HCM. Using advanced biophysical tools, researchers will explore how changes in MyBP-C structure and phosphorylation impact heart muscle performance. This knowledge could lead to new insights into potential treatments for HCM.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with hypertrophic cardiomyopathy, particularly those with mutations in the MyBP-C gene.
Not a fit: Patients without hypertrophic cardiomyopathy or those with other unrelated cardiac conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new therapies for patients with hypertrophic cardiomyopathy.
How similar studies have performed: Previous research has shown promising results in understanding cardiac muscle dynamics, but this specific approach to studying MyBP-C is relatively novel.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COLSON, BRETT A — UNIVERSITY OF ARIZONA
- Study coordinator: COLSON, BRETT A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.