Understanding how a protein affects gum health and healing
Official title: The Role of Bone Sialoprotein in Modulating Periodontal Development and Repair
Funded at Ohio State University · NIH-10889973 · Data updated 2026-11-12
This study is looking at how a protein called bone sialoprotein helps with the healing of gums and teeth, which could lead to better treatments for people dealing with gum disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | August 1, 2023 |
| Project end | December 1, 2025 |
| Funding year | 2024 |
| Award (this year) | $54,774 |
| NIH project number | 5F30DE032897-02 |
| Project ID | NIH-10889973 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 30 and older who are experiencing periodontal disease or related dental issues.
✕Less likely to help
Patients with healthy gums and no history of periodontal disease may not benefit from this research.
What this research studies
This research investigates the role of bone sialoprotein in the development and repair of periodontal tissues, which are crucial for maintaining healthy teeth and gums. By studying how this protein influences the healing process in the mouth, the research aims to uncover new insights into periodontal disease, which affects a significant portion of adults. The approach includes examining the effects of bone sialoprotein in animal models to understand its impact on bone and tissue health. This could lead to improved therapies for those suffering from periodontal disease.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for periodontal disease, improving oral health and quality of life for patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of proteins in bone and tissue health, suggesting potential for success in this area as well.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Andras, Natalie Lynn — Ohio State University
- Study coordinator: Andras, Natalie Lynn
Related research
Other NIH-funded projects on the same topics.
-
Understanding how trinucleotide repeat expansions cause disease
A research project at Ohio State University is exploring how tiny DNA repeats become unstable and drive neurological and muscular diseases, with potential implications for future therapies.
-
Pediatric Prehospital Airway Resuscitation for Critically Ill Children
This grant tests the best way for paramedics to manage breathing tubes and other airways in seriously ill children before they reach the hospital.
-
From Social Breakups to Brain Changes in Alzheimer’s and Related Dementias
This grant explores how losing social connections may trigger brain changes and inflammation linked to Alzheimer’s disease and related dementias.
-
Understanding why patients with blood cancers start and stick with oral cancer medicines
A study to learn what helps or hinders Black patients with blood cancers in starting and continuing their prescribed oral cancer medicines.
-
How sex and hormones affect alcohol's impact on sleep in adults
This study tests how sex and hormone changes influence how alcohol disrupts sleep in healthy adults, with a focus on women aged 21-45.
-
Natural products to block IL-8 signaling and prevent Barrett's Esophagus from turning into esophageal cancer
A搜索-friendly plan to use safe natural compounds to interrupt a key inflammatory signal (IL-8) and stop Barrett’s esophagus from turning into esophageal cancer in people with GERD.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.