Understanding how a protein affects fat production in the liver
Official title: The role of FIT2 in VLDL assembly, hepatic triglyceride homeostasis, and lipoprotein atherogenicity
Funded at New York University School of Medicine · NIH-11053474 · Data updated 2026-11-12
This study is looking at how a protein called FIT2 helps liver cells make certain fats that are important for your body, which could lead to better understanding and treatments for fat-related health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 6, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $172,405 |
| NIH project number | 5R01HL168569-03 |
| Project ID | NIH-11053474 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with metabolic disorders or conditions related to lipid metabolism, such as atherosclerosis or fatty liver disease.
✕Less likely to help
Patients who do not have metabolic disorders or related cardiovascular conditions may not benefit from this research.
What this research studies
This research investigates the role of a protein called FIT2 in the production of very low-density lipoproteins (VLDLs) in liver cells, which are crucial for fat metabolism. The study aims to uncover how FIT2 influences the assembly of triglycerides onto apolipoprotein B, a key component of VLDLs, and how this process is regulated within liver cells. By using advanced rodent models and in vitro techniques, the researchers will explore the mechanisms that control lipid assembly and secretion, potentially leading to new insights into liver function and fat-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of conditions related to fat metabolism and cardiovascular diseases.
How similar studies have gone: Previous research has shown success in understanding lipid metabolism and its implications for cardiovascular health, suggesting that this approach may yield valuable insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Fisher, Edward a — New York University School of Medicine
- Study coordinator: Fisher, Edward a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.