Understanding how a protein affects fat breakdown in the body
Official title: ABHD5 Enzymatic Function and Role in Lipolysis
Funded at Brooklyn College · NIH-10359860 · Data updated 2026-11-12
This study is looking at how a protein called ABHD5 helps your body break down fats, which is important for understanding issues like diabetes and obesity, especially if there are changes in this protein that could affect your health.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brooklyn College NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 17, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2021 |
| Award (this year) | $451,236 |
| NIH project number | 1R15DK131627-01 |
| Project ID | NIH-10359860 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with metabolic disorders related to fat metabolism, such as diabetes or obesity.
✕Less likely to help
Patients who do not have metabolic disorders or conditions related to fat metabolism may not benefit from this research.
What this research studies
This research investigates the role of the ABHD5 protein in breaking down fats in the body, particularly focusing on its function in the catabolism of triacylglycerol. The study aims to clarify how ABHD5 interacts with other enzymes involved in fat metabolism and how mutations in this protein can lead to various health issues. By conducting enzymology studies, researchers will explore the mechanisms by which ABHD5 influences fat storage and breakdown, which could have implications for conditions like diabetes and obesity.
Why it matters
Potential benefit: If successful, this research could lead to new insights into fat metabolism disorders and potential therapeutic targets for conditions like diabetes and obesity.
How similar studies have gone: Previous research has shown promising results in understanding fat metabolism through similar enzymatic studies, indicating that this approach has potential for success.
Where this research is happening
-
Brooklyn College
New York, United States Active
Researchers
- Principal investigator: Caviglia, Jorge Matias — Brooklyn College
- Study coordinator: Caviglia, Jorge Matias
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.