Understanding how a protein affects embryo development and fertility
Defining the role of DOT1L in chromocenter stabilization pre- and post-fertilization
['FUNDING_R21'] · YALE UNIVERSITY · NIH-10739438
This study is looking at how a protein called DOT1L helps shape important structures in our cells during the early stages of embryo development, which could help us understand some fertility problems.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10739438 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called DOT1L in the structural changes of chromatin that occur before and after fertilization. It focuses on how chromocenters, which are important nuclear structures, are formed and maintained during the early stages of embryo development. By studying these processes, the research aims to identify the molecular signals that regulate chromocenter disassembly in sperm and their reassembly in embryos. This could provide insights into fertility issues related to chromatin organization.
Who could benefit from this research
Good fit: Ideal candidates for this research are couples experiencing infertility or difficulties conceiving.
Not a fit: Patients who are not seeking to conceive or who have no fertility issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for addressing infertility by improving our understanding of embryo viability.
How similar studies have performed: Other research has shown promising results in understanding chromatin dynamics and its impact on fertility, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LESCH, BLUMA J — YALE UNIVERSITY
- Study coordinator: LESCH, BLUMA J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.