Understanding how a protein affects different eye diseases
The differential behavior of Prph2/Rom1 in rods and cone contributes to Prph2-associated disease heterogeneity
This study is looking at how a protein called Peripherin 2 affects eye diseases like retinitis pigmentosa and macular degeneration, to help us understand why these conditions vary in severity and to find better treatments for people with these inherited retinal diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10913476 on NIH RePORTER |
What this research studies
This research investigates the role of the Peripherin 2 (PRPH2) protein in various inherited retinal diseases, such as retinitis pigmentosa and macular degeneration. By using advanced imaging techniques and animal models, the study aims to uncover how mutations in PRPH2 lead to diverse disease outcomes. The researchers are particularly focused on how PRPH2 interacts with another protein, Rom1, and how this relationship influences the severity of eye diseases. The goal is to enhance our understanding of these conditions and pave the way for future therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with inherited retinal diseases linked to mutations in the PRPH2 gene.
Not a fit: Patients with retinal diseases not associated with PRPH2 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with inherited retinal diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of PRPH2 in retinal diseases, indicating that this approach has potential for success.
Where this research is happening
Houston, United States
- University of Houston — Houston, United States (Active)
Researchers
- Principal investigator: Ikelle, Larissa — University of Houston
- Study coordinator: Ikelle, Larissa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.