Understanding how a protein affects cell survival and death in response to inflammation
Biomedical Research and Research Training
This study is looking at how a protein called TNF affects whether cells live or die, especially in the context of diseases related to chronic inflammation, and it involves testing cells from patients and animals to understand how certain genetic changes might influence these processes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project ID | NIH-11095834 on NIH RePORTER |
What this research studies
This research investigates the role of tumor necrosis factor (TNF) in regulating cell survival and death, focusing on the molecular mechanisms that determine these outcomes. By studying how TNF signaling is influenced by post-translational modifications, particularly through a protein complex called LUBAC, the research aims to uncover why some cells survive while others undergo apoptosis. The approach includes using patient-derived cells and animal models to explore the effects of genetic mutations on these processes. This could lead to insights into chronic inflammation and related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic mutations affecting TNF signaling or related pathways.
Not a fit: Patients with conditions unrelated to TNF signaling or those not exhibiting chronic inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions characterized by chronic inflammation and cell death.
How similar studies have performed: Previous research has shown promising results in understanding TNF signaling and its implications for cell survival, indicating that this approach has potential for significant findings.
Where this research is happening
Austin, United States
- University of Texas at Austin — Austin, United States (Active)
Researchers
- Principal investigator: Lopez-Mosqueda, Jaime — University of Texas at Austin
- Study coordinator: Lopez-Mosqueda, Jaime
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.