Understanding how a protein affects cell division in cancer
Official title: Defining the mechanisms by which NuMA drives spindle mechanical robustness
Funded at University of California, San Francisco · NIH-10973546 · Data updated 2026-11-12
This study is looking at a protein called NuMA to understand how it helps cells divide correctly, which is important for preventing cancer, and it hopes to find new ways to treat cancers that happen when cells don’t divide properly.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $45,456 |
| NIH project number | 5F31CA275394-02 |
| Project ID | NIH-10973546 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers characterized by aneuploidy or those at risk of developing such cancers.
✕Less likely to help
Patients with cancers not associated with chromosome segregation errors may not benefit from this research.
What this research studies
This research investigates the role of a protein called NuMA in ensuring proper cell division, which is crucial for preventing cancer. It focuses on how NuMA contributes to the mechanical stability of the spindle, a structure that separates chromosomes during cell division. By examining how changes in NuMA function can lead to errors in chromosome segregation, the research aims to uncover potential targets for cancer treatment. Patients may benefit from insights gained about how to prevent or treat cancers associated with aneuploidy.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating certain types of cancer linked to chromosome segregation errors.
How similar studies have gone: Previous research has shown that targeting mechanisms involved in chromosome segregation can lead to significant advancements in cancer treatment, indicating a promising avenue for this investigation.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Cho, Nathan — University of California, San Francisco
- Study coordinator: Cho, Nathan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.