Understanding how a protein affects cancer cell invasion
Regulation of the extracellular HSP90 chaperone machinery
This study is looking at a protein called eHSP90 to understand how it helps cancer cells spread, with the hope of finding new treatments that can stop this spread and improve care for cancer patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-10741824 on NIH RePORTER |
What this research studies
This research investigates the role of the extracellular heat shock protein 90 (eHSP90) in cancer cell invasion, focusing on how it interacts with other proteins and molecules in the body. The researchers aim to uncover the regulatory mechanisms that control eHSP90, which could lead to new therapies that prevent tumor cells from invading surrounding tissues. By studying the effects of ATP and specific protein modifications on eHSP90, they hope to develop targeted treatments for various cancers. Patients may benefit from advancements in therapies that inhibit cancer progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with cancers that involve tumor cell invasion.
Not a fit: Patients with non-cancerous conditions or those whose cancers do not involve eHSP90 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively prevent cancer cell invasion and improve treatment outcomes for patients.
How similar studies have performed: Previous research has shown promising results in targeting heat shock proteins for cancer treatment, suggesting that this approach may be viable.
Where this research is happening
Syracuse, United States
- Upstate Medical University — Syracuse, United States (Active)
Researchers
- Principal investigator: Bourboulia, Dimitra — Upstate Medical University
- Study coordinator: Bourboulia, Dimitra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.