Understanding how a protein affects breast cancer spread
Profilin biology in breast cancer
This study is looking at how a protein called profilin1 affects the movement of breast cancer cells, with the goal of finding new ways to stop the cancer from spreading.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11039947 on NIH RePORTER |
What this research studies
This research investigates the role of profilin1, a protein that regulates the actin cytoskeleton, in the spread of breast cancer cells. The study aims to uncover how profilin1 influences cell signaling at the interface between the cell membrane and cytosol, which is crucial for the early stages of cancer metastasis. Researchers will use advanced techniques such as live cell imaging and analysis of clinical samples to explore the dynamics of membrane signaling and its impact on cancer cell movement. By understanding these mechanisms, the research seeks to identify new targets for preventing breast cancer metastasis.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with breast cancer, particularly those at risk of metastasis.
Not a fit: Patients with non-breast cancers or those whose breast cancer is already at an advanced metastatic stage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing the spread of breast cancer, potentially improving survival rates.
How similar studies have performed: Previous research has shown promising results in understanding the role of actin-regulatory proteins in cancer metastasis, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Roy, Partha — University of Pittsburgh at Pittsburgh
- Study coordinator: Roy, Partha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.