Understanding how a protein affects brain swelling after a stroke
Aquaporin-4 regulation by NCX1 in post-ischemic brain swelling
This study is looking at how a protein called aquaporin-4 affects brain swelling after a stroke, and it aims to find out how certain processes in brain cells can help us understand and possibly reduce this swelling in people who have had a stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10865128 on NIH RePORTER |
What this research studies
This research investigates the role of aquaporin-4 (AQP4) in brain swelling following ischemic stroke. It focuses on how the regulation of AQP4 by the sodium/calcium exchanger 1 (NCX1) and calcium-dependent mechanisms can influence water transport in brain cells. By studying mouse brain tissues after stroke, the research aims to uncover the mechanisms that lead to brain edema and dysfunction of the blood-brain barrier. This could provide insights into potential therapeutic targets for reducing brain swelling in stroke patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an ischemic stroke and are suffering from brain edema.
Not a fit: Patients with non-ischemic strokes or those without significant brain swelling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce brain swelling and improve recovery outcomes for stroke patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of AQP4 in brain edema, but this specific approach is relatively novel.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Simard, J. Marc — University of Maryland Baltimore
- Study coordinator: Simard, J. Marc
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.