Understanding how a protein affects brain health in Alzheimer's and frontotemporal dementia
Resolving the function of progranulin in lysosomal lipid metabolism and the etiology of Alzheimer's disease and frontotemporal dementia
['FUNDING_OTHER'] · EMORY UNIVERSITY · NIH-10526035
This study is looking at how a protein called progranulin affects brain health and may play a role in Alzheimer's disease and frontotemporal dementia, with the hope of finding new ways to help people with these conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-10526035 on ClinicalTrials.gov |
What this research studies
This research investigates the role of progranulin, a protein linked to brain health, in the development of Alzheimer's disease and frontotemporal dementia. The study aims to uncover how the loss of this protein leads to problems in lysosomal function and lipid metabolism, which are critical for maintaining healthy brain cells. By analyzing genetic variants and their effects on brain health, the research seeks to identify potential pathways that contribute to neurodegeneration. Patients may benefit from insights that could lead to new therapeutic strategies targeting these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic predispositions to Alzheimer's disease or frontotemporal dementia.
Not a fit: Patients with other forms of dementia unrelated to the mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve brain health and slow the progression of Alzheimer's disease and frontotemporal dementia.
How similar studies have performed: Previous research has shown promising results in understanding the role of lysosomal function in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KUKAR, THOMAS L — EMORY UNIVERSITY
- Study coordinator: KUKAR, THOMAS L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's Disease, Alzheimer disease, Alzheimer syndrome, Alzheimer's disease dementia, Alzheimers disease