Understanding how a protein affects brain development and function
Role of ATAD3A in Lysosomal Homeostasis and Neurogenesis
This study is looking at a protein called ATAD3A to understand how it helps keep our cells healthy and supports brain development, especially in people with neurological disorders, and it could lead to new treatments for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10910051 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called ATAD3A in maintaining cellular health and supporting brain development. By studying both fruit flies and human cells derived from patients, the researchers aim to uncover how mutations in ATAD3A lead to neurological disorders. The approach includes examining how ATAD3A influences nutrient sensing and the formation of lysosomes, which are crucial for cell function. The findings could provide insights into potential therapies for patients with related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with mutations in the ATAD3A gene who experience neurological symptoms.
Not a fit: Patients without ATAD3A mutations or those with unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurological disorders associated with ATAD3A mutations.
How similar studies have performed: Other research has shown promising results in understanding the roles of similar proteins in neurological conditions, suggesting potential for success in this area.
Where this research is happening
Oklahoma City, United States
- Oklahoma Medical Research Foundation — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Yoon, Wan Hee — Oklahoma Medical Research Foundation
- Study coordinator: Yoon, Wan Hee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.