Understanding how a protein affects blood vessel function in children with sepsis
Mechanisms driving endothelial angiopoietin-2 expression and vascular dysfunction during pediatric sepsis
This study is looking at how a protein called angiopoietin-2 might cause blood vessel issues in children with sepsis, with the hope of finding new ways to help them recover better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10909950 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called angiopoietin-2 (Ang-2) in causing blood vessel problems during pediatric sepsis. The study aims to uncover how Ang-2 contributes to organ injury in children suffering from this serious condition. By examining blood samples and endothelial cells, researchers will explore the mechanisms that lead to increased Ang-2 levels and how this protein interacts with other cellular components. The goal is to identify potential targets for new treatments that could improve outcomes for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are diagnosed with sepsis.
Not a fit: Patients who are not diagnosed with sepsis or are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that reduce organ damage and improve survival rates in children with sepsis.
How similar studies have performed: Previous research has shown that targeting similar pathways in vascular dysfunction has led to promising outcomes, indicating potential for success in this area.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Richter, Robert P — University of Alabama at Birmingham
- Study coordinator: Richter, Robert P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.