Understanding how a protein affects blood flow in limbs
Deciphering the regulatory role of matricelluar protein CCN3 in functional collateral blood flow
This study is looking at a protein called CCN3 to see how it helps improve blood flow in people with peripheral artery disease, especially those with severe leg pain, and aims to find new treatments that could work alongside current options to help them feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10594955 on NIH RePORTER |
What this research studies
This research investigates the role of the matricellular protein CCN3 in regulating blood flow in patients with peripheral artery disease (PAD), particularly those suffering from critical limb ischemia (CLI). The study aims to uncover the mechanisms by which CCN3 influences endothelial function and neovascularization, which are crucial for restoring blood flow in affected limbs. By using animal models and analyzing tissue samples from patients, the researchers hope to identify new therapeutic strategies that could improve outcomes for individuals with PAD. The ultimate goal is to develop novel pharmacologic therapies that can be combined with existing treatment options to enhance vascular function.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with peripheral artery disease, particularly those experiencing critical limb ischemia.
Not a fit: Patients with mild forms of peripheral artery disease or those without significant vascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve blood flow and reduce complications for patients with critical limb ischemia.
How similar studies have performed: Previous research has shown promising results in understanding the role of matricellular proteins in vascular health, suggesting that this approach may yield valuable insights.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Lin, Zhiyong — Emory University
- Study coordinator: Lin, Zhiyong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.