Understanding how a protein affects Alzheimer's disease
Regulation of SORLA by beta-arrestin2
['FUNDING_R01'] · AUGUSTA UNIVERSITY · NIH-10875755
This study is looking at how a protein called SORLA, which helps protect against Alzheimer's disease, works with another protein called beta-arrestin2, and by studying brain tissues from people with Alzheimer's, the researchers hope to find new ways to help improve treatment for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | AUGUSTA UNIVERSITY (nih funded) |
| Locations | 1 site (AUGUSTA, UNITED STATES) |
| Trial ID | NIH-10875755 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called SORLA in Alzheimer's disease, focusing on how it is regulated by another protein, beta-arrestin2. The study aims to uncover the mechanisms behind SORLA's protective effects against the disease and how its interaction with beta-arrestin2 may influence Alzheimer's pathology. By examining brain tissues from Alzheimer's patients, the researchers hope to identify potential new treatment strategies that could improve patient outcomes. The approach includes both genetic analysis and biochemical studies to understand these interactions better.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a genetic predisposition to Alzheimer's disease or those diagnosed with early-onset Alzheimer's.
Not a fit: Patients with non-Alzheimer's forms of dementia or those without any genetic risk factors for Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for Alzheimer's disease that target the regulation of SORLA.
How similar studies have performed: Previous research has shown promising results in understanding the genetic factors of Alzheimer's disease, but the specific interaction between SORLA and beta-arrestin2 is a novel area of investigation.
Where this research is happening
AUGUSTA, UNITED STATES
- AUGUSTA UNIVERSITY — AUGUSTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, QIN — AUGUSTA UNIVERSITY
- Study coordinator: WANG, QIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease