Understanding how a protein affects allergic reactions in mast cells
Official title: NHERF1 regulates MRGPRX2/MrgprB2 responses in mast cells
Funded at Michigan State University · NIH-10711042 · Data updated 2026-11-12
This study is looking at how a protein called NHERF1 affects mast cells, which play a big role in allergic reactions, to better understand how they respond in conditions like asthma and hives, with the hope of finding new treatments for these allergies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | July 12, 2023 |
| Project end | June 30, 2029 |
| Funding year | 2023 |
| Award (this year) | $460,688 |
| NIH project number | 1R01AI177305-01 |
| Project ID | NIH-10711042 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with allergic diseases such as asthma, hives, or those experiencing pseudoallergic reactions.
✕Less likely to help
Patients without allergic conditions or those not affected by mast cell-related disorders may not benefit from this research.
What this research studies
This research investigates the role of a specific protein, NHERF1, in regulating responses of mast cells, which are crucial for allergic reactions. The study focuses on a receptor known as MRGPRX2, which is linked to pseudoallergic reactions and chronic inflammation in conditions like asthma and hives. By using advanced mouse models and human-derived mast cells, the research aims to uncover the molecular mechanisms behind these responses, potentially leading to new therapeutic strategies for allergic diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from allergic reactions and related conditions.
How similar studies have gone: Previous research has shown promising results in understanding mast cell functions and their role in allergic responses, indicating that this approach has potential for success.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: Laumet, Geoffroy O — Michigan State University
- Study coordinator: Laumet, Geoffroy O
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.