Understanding how a parvovirus replicates in liver cells
Mechanisms of parvovirus replication in viral hepatitis
This study is looking at how a new virus called Equine parvovirus-Hepatitis affects liver cells, especially how it grows and interacts with the cell's natural processes, to help us understand its impact on liver health.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10888330 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which a novel parvovirus, known as Equine parvovirus-Hepatitis (EqPV-H), replicates in liver cells. The study focuses on how this virus interacts with the cell cycle and the DNA damage response in hepatocytes, which are the main cells in the liver. By examining these interactions, researchers aim to uncover important insights into the virus's behavior and its potential effects on liver health. The research involves both in vivo and in vitro experiments to assess the cellular conditions that facilitate viral replication and associated liver damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with liver conditions or those who may be at risk of hepatitis caused by parvoviruses.
Not a fit: Patients with liver diseases not associated with viral infections or those who do not have any liver-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for liver diseases associated with parvoviruses.
How similar studies have performed: While the study of animal viruses has provided insights into human diseases, the specific mechanisms of EqPV-H replication in liver cells are relatively novel and have not been extensively tested in human contexts.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Jager, Mason Cameron — Cornell University
- Study coordinator: Jager, Mason Cameron
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.