Understanding how a parasite regulates its internal structures to survive in host cells
Kinase regulation of trafficking at the Toxoplasma intravacuolar network
This study is looking at how the Toxoplasma gondii parasite survives and grows inside our cells, focusing on a special part of the cell that helps it thrive, with the goal of finding new ways to treat infections caused by this common parasite.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10793502 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the Toxoplasma gondii parasite manages to thrive within host cells. It focuses on a specialized organelle called the parasitophorous vacuole, where the parasite resides and replicates. The study aims to understand how certain proteins, regulated by a specific kinase, contribute to the formation and function of the intravacuolar network, which is crucial for the parasite's survival and virulence. By examining these processes, the research seeks to uncover potential targets for therapeutic intervention against infections caused by this widespread parasite.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are immunocompromised or have a history of Toxoplasma gondii infection.
Not a fit: Patients who are healthy and have no history of Toxoplasma infection are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for Toxoplasma infections, particularly in vulnerable populations such as the immunocompromised.
How similar studies have performed: Previous research has shown success in targeting similar mechanisms in other parasitic infections, indicating potential for this approach.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Reese, Michael Lloyd — Ut Southwestern Medical Center
- Study coordinator: Reese, Michael Lloyd
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.