Understanding how a parasite infects human cells and causes disease
Official title: Investigating the molecular composition of the parasitophorous vacuole during Encephalitozoon intestinalis infection
Funded at New York University School of Medicine · NIH-10902725 · Data updated 2026-11-12
This study is looking at how a tiny parasite called Encephalitozoon intestinalis infects human cells and survives, which could help us find new ways to treat infections caused by it.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $41,614 |
| NIH project number | 1F31AI183707-01 |
| Project ID | NIH-10902725 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are immunocompromised or have been diagnosed with infections caused by Encephalitozoon intestinalis.
✕Less likely to help
Patients with infections caused by other pathogens or those who are not immunocompromised may not benefit from this research.
What this research studies
This research investigates how the parasite Encephalitozoon intestinalis infects human cells and the mechanisms it uses to survive and replicate within the host. By examining the molecular composition of the parasitophorous vacuole, a protective compartment formed by the parasite, the study aims to uncover how the parasite interacts with host cells and acquires nutrients. The research employs advanced imaging techniques to visualize the parasite's developmental stages and its relationship with host organelles, which could provide insights into potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for infections caused by Encephalitozoon intestinalis, particularly for vulnerable populations such as immunocompromised individuals.
How similar studies have gone: While research on microsporidia is ongoing, this specific investigation into the molecular interactions within the parasitophorous vacuole is relatively novel and has not been extensively studied.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Mccarty, Kacie — New York University School of Medicine
- Study coordinator: Mccarty, Kacie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.