Understanding how a nutrient called methionine affects health and disease, especially in cancer
Deciphering the crosstalk between methionine metabolism and methyltransferases in health and disease
['FUNDING_OTHER'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11136413
This research explores how the body uses a key nutrient, methionine, and how its balance impacts cell health and diseases like cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11136413 on ClinicalTrials.gov |
What this research studies
Our bodies rely on a nutrient called methionine for many important cell functions, including making proteins and protecting cells from damage. When the body's use of methionine is out of balance, it can contribute to various diseases. This project aims to uncover the specific ways that changes in methionine levels lead to these health problems. We want to identify the exact cellular processes and molecules that connect methionine metabolism to the development of diseases, including different types of cancer. By understanding these connections, we hope to find new ways to address these conditions.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to understand disease mechanisms relevant to individuals with various conditions, particularly cancers, where methionine metabolism is altered.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science research, as it focuses on understanding disease mechanisms rather than clinical intervention.
Why it matters
Potential benefit: If successful, this work could reveal new targets for therapies that help restore healthy cell function and treat diseases like cancer by adjusting methionine metabolism.
How similar studies have performed: While the broad importance of methionine metabolism is known, this research aims to uncover novel, specific molecular links that are currently not well understood.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PARKHITKO, ANDREY A — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: PARKHITKO, ANDREY A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers