Understanding how a new type of fat cell affects bone health
Control of bone physiology by a novel type of adipose cells
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-11054568
This study is looking at a new type of fat cell that might help keep our bones healthy and prevent osteoporosis, especially in older adults, by understanding how these cells work with other bone cells to support bone strength.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11054568 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a newly identified type of fat cell, called marrow adipogenic lineage precursors (MALPs), in maintaining bone health and preventing osteoporosis. By analyzing single-cell data, the study aims to uncover how these cells interact with other bone cells and contribute to bone remodeling. The goal is to identify new therapeutic targets that could lead to better treatments for conditions like low bone mass and osteoporosis, particularly in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 65 and older who are at risk for osteoporosis or have low bone mass.
Not a fit: Patients under the age of 65 or those without bone health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve bone health and reduce the risk of fractures in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the role of different cell types in bone health, suggesting that this approach could yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: QIN, LING — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: QIN, LING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.