Understanding how a new receptor in the immune system responds to cell injury
Immunobiology of a novel human DAMP receptor, its murine homolog, & their ligand
This study is looking at a special part of our immune system that helps it respond to damaged cells, and it aims to understand how this part works with a specific protein released when cells are hurt, which could help find new ways to treat conditions like stroke and heart injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11132308 on NIH RePORTER |
What this research studies
This research investigates a novel receptor in the human immune system that detects signals from damaged cells, known as Damage Associated Molecular Patterns (DAMPs). The study aims to understand how this receptor, along with its mouse counterpart, interacts with a specific ligand called GAPDH, which is released during cell injury. By exploring the mechanisms of this interaction, the research seeks to uncover how these immune responses contribute to both health and disease, particularly in conditions like stroke and cardiac injury. Patients may benefit from insights that could lead to new therapeutic strategies for managing inflammation and tissue damage.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced cell injury or conditions related to inflammation, such as stroke or heart attack.
Not a fit: Patients with stable, non-inflammatory conditions or those not experiencing any form of cell injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage inflammation and tissue damage in various diseases.
How similar studies have performed: Previous research has shown promising results in understanding DAMPs and their receptors, but this specific receptor and ligand interaction is relatively novel and less explored.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Lai, Jiann-Jyh — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Lai, Jiann-Jyh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.