Understanding how a new protein affects brain development and function
Official title: Defining the function of a novel insulin-like growth factor binding protein in CNS development and function
Funded at Case Western Reserve University · NIH-10994420 · Data updated 2026-11-12
This study is looking at a new protein called Crimpy in fruit flies to see how it helps the brain develop and work, especially in areas like sleep and learning, which could eventually help people with brain-related disorders.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $42,746 |
| NIH project number | 1F31NS139448-01 |
| Project ID | NIH-10994420 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with neurodevelopmental disorders or those interested in the biological mechanisms of brain function.
✕Less likely to help
Patients with conditions unrelated to neurodevelopment or insulin signaling may not receive any benefit from this research.
What this research studies
This research investigates the role of a novel insulin-like growth factor binding protein, known as Crimpy, in the development and function of the central nervous system (CNS). Using a model organism, Drosophila (fruit flies), the study aims to uncover how Crimpy influences neural circuit formation and behavior, particularly in relation to sleep and learning. The researchers will explore the cellular and molecular mechanisms by which Crimpy regulates insulin-like growth factor signaling in the brain, which could provide insights into neurodevelopmental disorders. Patients may benefit from this research as it could lead to new therapeutic targets for conditions related to misregulated insulin signaling.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodevelopmental disorders linked to insulin signaling.
How similar studies have gone: Other research has shown success in understanding insulin signaling in the brain, but the specific role of Crimpy in this context is novel and untested.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Rydbom, Jerrik — Case Western Reserve University
- Study coordinator: Rydbom, Jerrik
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.