Understanding how a new factor affects gene expression and chromatin structure
Official title: Investigate the function of NDF in chromatin dynamics and gene expression
Funded at Rutgers, the State Univ of N.j. · NIH-10977052 · Data updated 2026-11-12
This study is looking at a new factor called NDF that helps control how our genes work, and it's for anyone interested in understanding how our DNA is organized and how it affects gene activity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $296,731 |
| NIH project number | 5R01GM145748-03 |
| Project ID | NIH-10977052 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic conditions or diseases that may involve dysregulation of gene expression.
✕Less likely to help
Patients with conditions unrelated to chromatin dynamics or gene expression may not benefit from this research.
What this research studies
This research investigates a newly identified factor called NDF that plays a crucial role in the dynamics of chromatin and the process of gene expression. By employing advanced techniques such as ultra-high-resolution optical tweezers and cryo-electron microscopy, the researchers aim to understand how NDF destabilizes nucleosomes, which are structures that package DNA, thereby facilitating the elongation of RNA during transcription. The study will also explore how NDF is recruited to active genes and the implications of its absence on gene transcription. This comprehensive approach combines biochemistry, genomics, and bioinformatics to shed light on fundamental biological processes.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation, potentially impacting treatments for diseases linked to gene expression abnormalities.
How similar studies have gone: While the specific factor NDF is novel, similar approaches in studying chromatin dynamics have shown promise in understanding gene regulation.
Where this research is happening
-
Rutgers, the State Univ of N.j.
Piscataway, United States Active
Researchers
- Principal investigator: Fei, Jia — Rutgers, the State Univ of N.j.
- Study coordinator: Fei, Jia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.