Understanding how a new factor affects gene expression and chromatin structure
Investigate the function of NDF in chromatin dynamics and gene expression
This study is looking at a new factor called NDF that helps control how our genes work, and it's for anyone interested in understanding how our DNA is organized and how it affects gene activity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project ID | NIH-10977052 on NIH RePORTER |
What this research studies
This research investigates a newly identified factor called NDF that plays a crucial role in the dynamics of chromatin and the process of gene expression. By employing advanced techniques such as ultra-high-resolution optical tweezers and cryo-electron microscopy, the researchers aim to understand how NDF destabilizes nucleosomes, which are structures that package DNA, thereby facilitating the elongation of RNA during transcription. The study will also explore how NDF is recruited to active genes and the implications of its absence on gene transcription. This comprehensive approach combines biochemistry, genomics, and bioinformatics to shed light on fundamental biological processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or diseases that may involve dysregulation of gene expression.
Not a fit: Patients with conditions unrelated to chromatin dynamics or gene expression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation, potentially impacting treatments for diseases linked to gene expression abnormalities.
How similar studies have performed: While the specific factor NDF is novel, similar approaches in studying chromatin dynamics have shown promise in understanding gene regulation.
Where this research is happening
Piscataway, United States
- Rutgers, the State Univ of N.j. — Piscataway, United States (Active)
Researchers
- Principal investigator: Fei, Jia — Rutgers, the State Univ of N.j.
- Study coordinator: Fei, Jia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.